|
|
dopamine + secologanin <=> H2O + N-deacetylisoipecoside
|
4.3.3.3
deacetylisoipecoside synthase
|
–
|
MK
|
|
BRENDA:
BR26150
KEGG:
R05750
MetaCyc:
4.3.3.3-RXN
|
|
|
|
dopamine + secologanin <=> H2O + N-deacetylipecoside
|
4.3.3.4
deacetylipecoside synthase
|
–
|
K
|
|
BRENDA:
BR26151
KEGG:
R05749
MetaCyc:
4.3.3.4-RXN
|
|
|
|
tryptamine + secologanin <=> strictosidine + H2O
|
4.3.3.2
strictosidine synthase
|
–
|
MK
|
|
BRENDA:
BR48360
KEGG:
R03738
MetaCyc:
STRICTOSIDINE-SYNTHASE-RXN
|
|
|
|
S-adenosyl-L-methionine + secologanate <=> S-adenosyl-L-homocysteine + secologanin
|
2.1.1.50
loganate O-methyltransferase
|
–
|
K
|
|
BRENDA:
BS289542
KEGG:
R05834
MetaCyc:
RXN-4523
|
|
|
|
loganin + reduced_flavodoxin + O2 <=> secologanin + flavin + 2 H2O
|
1.14.19.62
secologanin synthase
|
–
|
K
|
|
BRENDA:
BR40360
KEGG:
R03555
|
|
|
|
secologanin <=> gentiopicroside
|
not assigned
|
–
|
K
|
|
KEGG:
R08500
|
|
|
|
loganin + O2 + reduced_[NADPH-hemoprotein_reductase] <=> secologanin + H2O + oxidized_[NADPH-hemoprotein_reductase]
|
1.14.19.62
secologanin synthase
|
–
|
M
|
|
MetaCyc:
1.3.3.9-RXN
|
|
|
|
loganin + NADPH + H+ + O2 <=> secologanin + NADP+ + 2 H2O
|
1.3.3.9
secologanin synthase
|
–
|
|
|
BRENDA:
BS442463
|
|
|
|
serotonin + secologanin <=> (4S,5R,6S)-4-((S)-6-hydroxy-2,3,4,9-tetrahydro-1H-b-carbolin-1-ylmethyl)-6-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-5-vinyl-5,6-dihydro-4H-pyran-3-carboxylic_acid_methyl_ester + H2O
|
4.3.3.2
strictosidine synthase
|
–
|
|
|
BRENDA:
BS381070
|
|
|
|
4-methyltryptamine + secologanin <=> (4S,5R,6S)-4-((S)-5-methyl-2,3,4,9-tetrahydro-1H-b-carbolin-1-ylmethyl)-6-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-5-vinyl-5,6-dihydro-4H-pyran-3-carboxylic_acid_methyl_ester + H2O
|
4.3.3.2
strictosidine synthase
|
–
|
|
|
BRENDA:
BS380906
|
|
|
|
2-benzofuran-3-yl-ethylamine + secologanin <=> (4S,5R,6S)-4-[(S)-1-(1,2,3,4-tetrahydro-benzo[4,5]furo[2,3-c]pyridin-1-yl)methyl]-6-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-5-vinyl-5,6-dihydro-4H-pyran-3-carboxylic_acid_methyl_ester + H2O
|
4.3.3.2
strictosidine synthase
|
–
|
|
|
BRENDA:
BS380979
|
|
|
|
2-(4-fluoro-1H-indol-3-yl)ethanamine + secologanin <=> (4S,5R,6S)-4-((S)-5-fluoro-2,3,4,9-tetrahydro-1H-b-carbolin-1-ylmethyl)-6-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-5-vinyl-5,6-dihydro-4H-pyran-3-carboxylic_acid_methyl_ester + H2O
|
4.3.3.2
strictosidine synthase
|
–
|
|
|
BRENDA:
BS380905
|
|
|
|
2-(7-fluoro-1H-indol-3-yl)ethanamine + secologanin <=> (4S,5R,6S)-4-((S)-8-fluoro-2,3,4,9-tetrahydro-1H-b-carbolin-1-ylmethyl)-6-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-5-vinyl-5,6-dihydro-4H-pyran-3-carboxylic_acid_methyl_ester + H2O
|
4.3.3.2
strictosidine synthase
|
–
|
|
|
BRENDA:
BS380909
|
|
|
|
7-methyltryptamine + secologanin <=> (4S,5R,6S)-4-((S)-8-methyl-2,3,4,9-tetrahydro-1H-b-carbolin-1-ylmethyl)-6-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-5-vinyl-5,6-dihydro-4H-pyran-3-carboxylic_acid_methyl_ester + H2O
|
4.3.3.2
strictosidine synthase
|
–
|
|
|
BRENDA:
BS380910
|
|
|
|
alpha-N-methyltryptamine + secologanin <=> dolichantoside + H2O
|
4.3.3.2
strictosidine synthase
|
–
|
|
|
BRENDA:
BS430446
|
|
|
|
5-fluorotryptamine + secologanin <=> (4S,5R,6S)-4-((S)-6-fluoro-2,3,4,9-tetrahydro-1H-b-carbolin-1-ylmethyl)-6-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-5-vinyl-5,6-dihydro-4H-pyran-3-carboxylic_acid_methyl_ester + H2O
|
4.3.3.2
strictosidine synthase
|
–
|
|
|
BRENDA:
BS380907
|
|
|
|
5-methoxytryptamine + secologanin <=> 10-methoxystrictosidine
|
4.3.3.2
strictosidine synthase
|
–
|
|
|
BRENDA:
BS363498
|
|
|
|
6-fluoro-tryptamine + secologanin <=> (4S,5R,6S)-4-((S)-7-fluoro-2,3,4,9-tetrahydro-1H-b-carbolin-1-ylmethyl)-6-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-5-vinyl-5,6-dihydro-4H-pyran-3-carboxylic_acid_methyl_ester + H2O
|
4.3.3.2
strictosidine synthase
|
–
|
|
|
BRENDA:
BS380908
|
|
|
|
2-(1-benzothien-3-yl)ethanamine + secologanin <=> (4S,5R,6S)-4-[(S)-1-(1,2,3,4-tetrahydro-benzo[4,5]thieno[2,3-c]pyridin-1-yl)methyl]-6-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-5-vinyl-5,6-dihydro-4H-pyran-3-carboxylic_acid_methyl_ester + H2O
|
4.3.3.2
strictosidine synthase
|
–
|
|
|
BRENDA:
BS380904
|
|
|
|
secologanin + H2O <=> secologanin_aglycone
|
3.2.1.125
raucaffricine beta-glucosidase
|
–
|
|
|
BRENDA:
BS417613
|
|
|
|
2-(4-fluoro-1H-indol-3-yl)ethanamine + secologanin <=> 4-fluoro-3-alpha(S)-strictosidine + H2O
|
4.3.3.2
strictosidine synthase
|
–
|
|
|
BRENDA:
BS399648
|
|
|
|
4-methyltryptamine + secologanin <=> 4-methyl-3-alpha(S)-strictosidine + H2O
|
4.3.3.2
strictosidine synthase
|
–
|
|
|
BRENDA:
BS399666
|
|
|
|
5-fluorotryptamine + secologanin <=> 5-fluoro-3-alpha(S)-strictosidine + H2O
|
4.3.3.2
strictosidine synthase
|
–
|
|
|
BRENDA:
BS399724
|
|
|
|
6-fluoro-tryptamine + secologanin <=> 6-fluoro-3-alpha(S)-strictosidine + H2O
|
4.3.3.2
strictosidine synthase
|
–
|
|
|
BRENDA:
BS399757
|
|
|
|
6-methoxy-tryptamine + secologanin <=> 6-methoxy-3-alpha(S)-strictosidine + H2O
|
4.3.3.2
strictosidine synthase
|
–
|
|
|
BRENDA:
BS399764
|
|
|
|
6-methyl-tryptamine + secologanin <=> 6-methyl-3-alpha(S)-strictosidine + H2O
|
4.3.3.2
strictosidine synthase
|
–
|
|
|
BRENDA:
BS399765
|
|
|
|
2-(7-fluoro-1H-indol-3-yl)ethanamine + secologanin <=> 7-fluoro-3-alpha(S)-strictosidine + H2O
|
4.3.3.2
strictosidine synthase
|
–
|
|
|
BRENDA:
BS399774
|
|
|
|
7-methyltryptamine + secologanin <=> 7-methyl-3-alpha(S)-strictosidine + H2O
|
4.3.3.2
strictosidine synthase
|
–
|
|
|
BRENDA:
BS399778
|
|
|
|
serotonin + secologanin <=> 5-hydroxy-3-alpha(S)-strictosidine + H2O
|
4.3.3.2
strictosidine synthase
|
–
|
|
|
BRENDA:
BS401888
|
|
|
|
7-azatryptamine + secologanin <=> 3-alpha(S)-12-azastrictosidine
|
4.3.3.2
strictosidine synthase
|
–
|
|
|
BRENDA:
BS408230
|
|